This case series highlights that these patients can have high mortality rates and additional clinical attention may be warranted. Excursions from the normal care of these patients may be required to gain euglycemia, including, but not limited to, administration of higher insulin concentrations. Based on this review, the purpose of this letter is to draw further attention to the need for further studies evaluating patients positive for COVID-19 requiring ≥100 units/hour of insulin and its impact on COVID-19 treatment outcomes.