International Hospital Diabetes Meeting


May 2015


Melanie Mabrey, Joseph Aloi, Paul Chidester, Jagdeesh Ullal, Amy Henderson, Raymie McFarland, Robby Booth


American Diabetes Association guidelines recommend a basal bolus correction insulin regimen as the preferred method of treatment for non-critically ill hospitalized patients. The target for premeal blood glucose (BG) of <140 mg/dL and random BG of <180 mg/dL are well defined. However, achieving these targets safely, without hypoglycemia, is challenging. With this study we evaluated glycemic control with fasting and pre-prandial BGs for patients using Glucommander Subcutaneous (GM SubQ) treatment for insulin therapy.


769 patients treated with GM SubQ insulin therapy were evaluated. Qualifying patients had two BGs >180 mg/dL in 24 hours and required insulin. The target glucose was set at 100-140 mg/dL fasting and pre-prandial. The safety and efficacy was evaluated at the following time points: before each meal (breakfast, lunch, dinner) and at bedtime via (1) BG averages, (2) BG reductions, and (3) hypoglycemic events <70 mg/dL and <40 mg/dL.


Patients treated on GM SubQ achieved an average pre-prandial BG at breakfast of 119 mg/dL, lunch 131 mg/dL, dinner 126 mg/dL and bedtime of 116 mg/dL. Initial BG average was 227 mg/dL. BG average over length of stay was 132 mg/dL.

Reduction of BG at breakfast was 84 mg/dL, lunch 106 mg/dL, dinner 100 mg/dL, and bedtime 105 mg/dL. Average BG reduction was 98.75 mg/dL. Hypoglycemia <70 mg/dL at breakfast was 2.3%, lunch 1.9%, dinner 3.0% and bedtime 2.0%. Hypoglycemia <40 mg/dL at breakfast was 0.0%, lunch 0.1%, dinner 0.1% and bedtime 0.1%.

Category Data
Patients 769
Initial BG Average 227 mg/dL
Glucommander BG Average 132 mg/dL
Hypoglycemia <70 mg/dL – Breakfast 2.3%
Hypoglycemia <70 mg/dL – Lunch 1.9%
Hypoglycemia <70 mg/dL – Dinner 3.0%
Hypoglycemia <70 mg/dL – Bedtime 2.0%
Hypoglycemia <40 mg/dL – Breakfast 0.0%
Hypoglycemia <40 mg/dL – Lunch 0.1%
Hypoglycemia <40 mg/dL – Dinner 0.1%
Hypoglycemia <40 mg/dL – Bedtime 0.1%


Patients using GM SubQ achieved prescribed glycemic target at each meal and bedtime with low incidence of hypoglycemia (<70 mg/dL & <40 mg/dL). These results suggest GM SubQ can maintain glucose control in ADA recommended targets without increased risk of hypoglycemia.

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